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Multiple loop structures critical for ligand binding of the integrin α4 subunit in the upper face of the β-propeller mode 1
A non-I-domain integrin, α4β1, recognizes vascular cell adhesion molecule 1 (VCAM-1) and the IIICS portion of fibronectin. To localize regions of α4 critical for ligand binding, we swapped several predicted loops within or near the putative ligand-binding site of α4 (which spans repeats 2–5 of the s...
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Hauptverfasser: | , , |
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Format: | Artigo |
Sprache: | Inglês |
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The National Academy of Sciences of the USA
1997
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Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC23791/ https://ncbi.nlm.nih.gov/pubmed/9207068 |
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