Multiple loop structures critical for ligand binding of the integrin α4 subunit in the upper face of the β-propeller mode 1
A non-I-domain integrin, α4β1, recognizes vascular cell adhesion molecule 1 (VCAM-1) and the IIICS portion of fibronectin. To localize regions of α4 critical for ligand binding, we swapped several predicted loops within or near the putative ligand-binding site of α4 (which spans repeats 2–5 of the s...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1997
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23791/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9207068/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.14.7198 |
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