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Multiple loop structures critical for ligand binding of the integrin α4 subunit in the upper face of the β-propeller mode 1

A non-I-domain integrin, α4β1, recognizes vascular cell adhesion molecule 1 (VCAM-1) and the IIICS portion of fibronectin. To localize regions of α4 critical for ligand binding, we swapped several predicted loops within or near the putative ligand-binding site of α4 (which spans repeats 2–5 of the s...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Irie, Atsushi, Kamata, Tetsuji, Takada, Yoshikazu
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23791/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9207068/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.14.7198
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