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Resistance of a human serum-selected human immunodeficiency virus type 1 escape mutant to neutralization by CD4 binding site monoclonal antibodies is conferred by a single amino acid change in gp120.

We have selected an HXB2 variant which can replicate in the presence of a neutralizing human serum. Sequencing of the gp120 region of the env gene from the variant and parental viruses identified a single amino acid substitution in the third conserved region of gp120 at residue 375 (AGT-->AAT, Ser--...

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Publicado no:J Virol
Principais autores: McKeating, J A, Bennett, J, Zolla-Pazner, S, Schutten, M, Ashelford, S, Brown, A L, Balfe, P
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237919/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7688820/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.9.5216-5225.1993
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