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Resistance of a human serum-selected human immunodeficiency virus type 1 escape mutant to neutralization by CD4 binding site monoclonal antibodies is conferred by a single amino acid change in gp120.

We have selected an HXB2 variant which can replicate in the presence of a neutralizing human serum. Sequencing of the gp120 region of the env gene from the variant and parental viruses identified a single amino acid substitution in the third conserved region of gp120 at residue 375 (AGT-->AAT, Se...

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Bibliografske podrobnosti
Main Authors: McKeating, J A, Bennett, J, Zolla-Pazner, S, Schutten, M, Ashelford, S, Brown, A L, Balfe, P
Format: Artigo
Jezik:Inglês
Izdano: 1993
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC237919/
https://ncbi.nlm.nih.gov/pubmed/7688820
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