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Arginine deprivation, growth inhibition and tumour cell death: 2. Enzymatic degradation of arginine in normal and malignant cell cultures
Arginase added to culture medium reduced arginine to negligible levels within ∼6 h, and enzyme activity persisted relatively undiminished for at least 3 days. Human and bovine arginase proved equally effective. The response of normal cells was to enter G1 (G0) arrest, from which most of the cells co...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2377179/ https://ncbi.nlm.nih.gov/pubmed/12592378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600681 |
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