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Arginine deprivation, growth inhibition and tumour cell death: 3. Deficient utilisation of citrulline by malignant cells

Arginine deprivation causes death of up to 80% of cancer cell lines in vitro, but in the body, citrulline would be available as a convertible source of this amino acid in vivo. Some tumour cell lines, notably the vast majority of melanomas and hepatocellular carcinomas, tend to be deficient in argin...

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Bibliografske podrobnosti
Main Authors: Wheatley, D N, Campbell, E
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394371/
https://ncbi.nlm.nih.gov/pubmed/12888832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601134
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