Apoptosis induction in renal cell carcinoma by TRAIL and γ-radiation is impaired by deficient caspase-9 cleavage

TNF-related apoptosis-inducing ligand (TRAIL APO-2L) is a member of the TNF family and induces apoptosis in cancer cells without affecting most non-neoplastic cells. The present investigation is focused on apoptosis induction by combined exposure to TRAIL and ionising radiation (IR) in human renal c...

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Autores principales: Ramp, U, Caliskan, E, Mahotka, C, Krieg, A, Heikaus, S, Gabbert, H E, Gerharz, C D
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377130/
https://ncbi.nlm.nih.gov/pubmed/12771998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600984
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