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Sequence Similarity Network Reveals Common Ancestry of Multidomain Proteins

We address the problem of homology identification in complex multidomain families with varied domain architectures. The challenge is to distinguish sequence pairs that share common ancestry from pairs that share an inserted domain but are otherwise unrelated. This distinction is essential for accura...

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Autori principali: Song, Nan, Joseph, Jacob M., Davis, George B., Durand, Dannie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377100/
https://ncbi.nlm.nih.gov/pubmed/18475320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000063
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