Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity

Platelet-derived endothelial cell growth factor (PD-ECGF)/thymidine phosphorylase (TP) catalyses the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate and is involved in the metabolism of fluoropyrimidines. It can also activate 5′-deoxyfluorouridine (5′DFUR) and possibl...

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Dettagli Bibliografici
Autori principali: de Bruin, M, van Capel, T, Van der Born, K, Kruyt, F A, Fukushima, M, Hoekman, K, Pinedo, H M, Peters, G J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2003
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377090/
https://ncbi.nlm.nih.gov/pubmed/12644837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600808
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