Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors

BACKGROUND: Thymidine phosphorylase (TP) is often overexpressed in tumours and has a role in tumour aggressiveness and angiogenesis. Here, we determined whether TP increased tumour invasion and whether TP-expressing cancer cells stimulated angiogenesis. METHODS: Angiogenesis was studied by exposing...

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Detalhes bibliográficos
Main Authors: Bijnsdorp, I V, Capriotti, F, Kruyt, F A E, Losekoot, N, Fukushima, M, Griffioen, A W, Thijssen, V L, Peters, G J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068508/
https://ncbi.nlm.nih.gov/pubmed/21386840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.74
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