Transcriptional impairment of β-catenin/E-cadherin complex is not associated with β-catenin mutations in colorectal carcinomas

We report the absence of β-catenin mutations in 63 sporadic colorectal carcinomas (SCRCs) with demonstrated decreased β-catenin and E-cadherin mRNA expression and E-cadherin protein expression in a subset of carcinomas examined, suggesting that β-catenin mutations are an extremely rare phenomenon in...

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Bibliographic Details
Main Authors: Garinis, G A, Spanakis, N E, Menounos, P G, Manolis, E N, Peros, G
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2003
Subjects:
Molecular and Cellular Pathology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377055/
https://ncbi.nlm.nih.gov/pubmed/12610504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600706
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