No major tumorigenic role for β-catenin in serrated as opposed to conventional colorectal adenomas

Intracellular redistribution of β-catenin through mutation of the adenomatous polyposis coli (APC) gene has been proposed as an early tumorigenic event in most colorectal tumours. In serrated adenoma (SA), a newly recognised subtype of colorectal adenoma, APC mutations are uncommon, and the contribu...

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Detalhes bibliográficos
Main Authors: Yamamoto, T, Konishi, K, Yamochi, T, Makino, R, Kaneko, K, Shimamura, T, Ota, H, Mitamura, K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2003
Assuntos:
Molecular and Cellular Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394200/
https://ncbi.nlm.nih.gov/pubmed/12838317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601070
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