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Increased expression of the ubiquitin – proteasome pathway in murine myotubes by proteolysis-inducing factor (PIF) is associated with activation of the transcription factor NF-κB

Proteolysis-inducing factor (PIF), isolated from a cachexia-inducing murine tumour, has been shown to stimulate protein breakdown in C(2)C(12) myotubes. The effect was attenuated by the specific proteasome inhibitor lactacystin and there was an elevation of proteasome ‘chymotrypsin-like’ enzyme acti...

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Detalhes bibliográficos
Main Authors: Whitehouse, A S, Tisdale, M J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376944/
https://ncbi.nlm.nih.gov/pubmed/12966435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601132
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