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Increased expression of the ubiquitin – proteasome pathway in murine myotubes by proteolysis-inducing factor (PIF) is associated with activation of the transcription factor NF-κB

Proteolysis-inducing factor (PIF), isolated from a cachexia-inducing murine tumour, has been shown to stimulate protein breakdown in C(2)C(12) myotubes. The effect was attenuated by the specific proteasome inhibitor lactacystin and there was an elevation of proteasome ‘chymotrypsin-like’ enzyme acti...

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Bibliografische gegevens
Hoofdauteurs: Whitehouse, A S, Tisdale, M J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2003
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376944/
https://ncbi.nlm.nih.gov/pubmed/12966435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601132
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