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Incidence, mechanism and prognostic value of activated AKT in pancreas cancer

When activated, the serine/threonine kinase AKT mediates an antiapoptotic signal implicated in chemoresistance of various cancers. The mechanism(s) of AKT activation are unknown, though overexpression of HER-2/neu has been implicated in breast cancer. Therefore, we determined the incidence of activa...

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Détails bibliographiques
Auteurs principaux: Schlieman, M G, Fahy, B N, Ramsamooj, R, Beckett, L, Bold, R J
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2003
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376856/
https://ncbi.nlm.nih.gov/pubmed/14647146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601396
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