ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

The RAS–ERK pathway is known to play a pivotal role in differentiation, proliferation and tumour progression. Here, we show that ERK downregulates Forkhead box O 3a (FOXO3a) by directly interacting with and phosphorylating FOXO3a at Ser 294, Ser 344 and Ser 425, which consequently promotes cell prol...

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Main Authors: Yang, Jer-Yen, Zong, Cong S., Xia, Weiya, Yamaguchi, Hirohito, Ding, Qingqing, Xie, Xiaoming, Lang, Jing-Yu, Lai, Chien-Chen, Chang, Chun-Ju, Huang, Wei-Chien, Huang, Hsin, Kuo, Hsu-Ping, Lee, Dung-Fang, Li, Long-Yuan, Lien, Huang-Chun, Cheng, Xiaoyun, Chang, King-Jen, Hsiao, Chwan-Deng, Tsai, Fuu-Jen, Tsai, Chang-Hai, Sahin, Aysegul A., Muller, William J., Mills, Gordon B., Yu, Dihua, Hortobagyi, Gabriel N., Hung, Mien-Chie
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376808/
https://ncbi.nlm.nih.gov/pubmed/18204439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1676
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