Activation of FOXO3a Is Sufficient to Reverse Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor Chemoresistance in Human Cancer

Drug resistance is a central challenge of cancer therapy that ultimately leads to treatment failure. In this study, we characterized a mechanism of drug resistance that arises to AZD6244, an established mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) 1/2 inhibitor curren...

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Bibliographic Details
Main Authors: Yang, Jer-Yen, Chang, Chun-Ju, Xia, Weiya, Wang, Yan, Wong, Kwok-Kin, Engelman, Jeffrey A., Du, Yi, Andreeff, Michael, Hortobagyi, Gabriel N., Hung, Mien-Chie
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895805/
https://ncbi.nlm.nih.gov/pubmed/20484037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4524
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