NF-κB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase

Hypoxic EMT-6 tumour cells displayed a high level of inducible nitric oxide synthase (iNOS) and an increased radiosensitivity after a 16 h exposure to lipopolysaccharide, a known activator of nuclear factor-κB (NF-κB). Both iNOS activation and radioresponse were impaired by the NF-κB inhibitors phen...

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Detalhes bibliográficos
Main Authors: Ridder, M De, Van den Berge, D L, Verovski, V N, Monsaert, C, Wauters, N, Storme, G A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2003
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376775/
https://ncbi.nlm.nih.gov/pubmed/12556970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600678
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