Radiosensitization of hypoxic tumour cells by S-nitroso-N-acetylpenicillamine implicates a bioreductive mechanism of nitric oxide generation

The radiosensitizing activity of S-nitroso-N-acetylpenicillamine (SNAP), a nitric oxide (NO) donor, was assessed in a model of non-metabolic hypoxia achieved in an atmosphere of 95% nitrogen–5% carbon dioxide. A 10 min preincubation of hypoxic EMT-6 cells (10 × 10(6) ml(−1)) with 0.1 and 1 mM SNAP b...

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Main Authors: Janssens, M Y, Verovski, V N, Van den Berge, D L, Monsaert, C, Storme, G A
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1999
Assuntos:
Regular Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362242/
https://ncbi.nlm.nih.gov/pubmed/10098740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690173
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