Marked inactivation of O(6)-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules

Temozolomide, an oral DNA methylator that inactivates the DNA repair enzyme O(6)-alkylguanine-DNA alkyltransferase (AGAT), has demonstrated anticancer activity on protracted schedules. Protracted schedules may lead to an ‘autoenhancement’ of temozolomide's inherent cytotoxic potential by cumula...

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Autors principals: Tolcher, A W, Gerson, S L, Denis, L, Geyer, C, Hammond, L A, Patnaik, A, Goetz, A D, Schwartz, G, Edwards, T, Reyderman, L, Statkevich, P, Cutler, D L, Rowinsky, E K
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2003
Matèries:
Clinical
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376384/
https://ncbi.nlm.nih.gov/pubmed/12671695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600827
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