Dose finding and O(6)-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies

Cisplatin may have additive activity with temozolomide due to ablation of the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT). This phase I/II study determined recommended combination doses using the Continual Reassessment Method, toxicities and antitumour activity in paediatric pat...

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Detalhes bibliográficos
Main Authors: Geoerger, B, Vassal, G, Doz, F, O'Quigley, J, Wartelle, M, Watson, A J, Raquin, M-A, Frappaz, D, Chastagner, P, Gentet, J-C, Rubie, H, Couanet, D, Geoffray, A, Djafari, L, Margison, G P, Pein, F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361608/
https://ncbi.nlm.nih.gov/pubmed/16136028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602740
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