CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours

We have recently shown that the CHEK2*1100delC mutation acts as a low penetrance breast cancer susceptibility allele. To investigate if other CHEK2 variants confer an increased risk of breast cancer, we have screened an affected individual with breast cancer from 68 breast cancer families. Five of t...

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Detalhes bibliográficos
Main Authors: Sodha, N, Bullock, S, Taylor, R, Mitchell, G, Guertl-Lackner, B, Williams, R D, Bevan, S, Bishop, K, McGuire, S, Houlston, R S, Eeles, R A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2002
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376278/
https://ncbi.nlm.nih.gov/pubmed/12454775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600637
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