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A Model for Oligomeric Regulation of APOBEC3G Cytosine Deaminase-dependent Restriction of HIV
APOBEC3G (A3G) restricts HIV-1 infection by catalyzing processive C → U deaminations on single-stranded DNA (ssDNA) with marked 3′ → 5′ deamination polarity. Here we show that A3G exists in oligomeric states whose composition is dictated primarily by interactions with DNA, with salt playing an impor...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2376223/ https://ncbi.nlm.nih.gov/pubmed/18362149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801004200 |
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