A Model for Oligomeric Regulation of APOBEC3G Cytosine Deaminase-dependent Restriction of HIV

APOBEC3G (A3G) restricts HIV-1 infection by catalyzing processive C → U deaminations on single-stranded DNA (ssDNA) with marked 3′ → 5′ deamination polarity. Here we show that A3G exists in oligomeric states whose composition is dictated primarily by interactions with DNA, with salt playing an impor...

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Bibliographic Details
Main Authors: Chelico, Linda, Sacho, Elizabeth J., Erie, Dorothy A., Goodman, Myron F.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376223/
https://ncbi.nlm.nih.gov/pubmed/18362149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801004200
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