Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum

In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be imp...

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Bibliografiske detaljer
Main Authors: Lees, N P, Harrison, K L, Hill, E, Hall, C N, Margison, G P, Povey, A C
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
Fag:
Molecular and Cellular Pathology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376118/
https://ncbi.nlm.nih.gov/pubmed/12107837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600455
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