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Human colorectal mucosal O(6)‐alkylguanine DNA‐alkyltransferase activity and DNA‐N7‐methylguanine levels in colorectal adenoma cases and matched referents
BACKGROUND AND AIMS: O(6)‐alkylguanine DNA‐alkyltransferase (MGMT) provides protection against alkylating agent‐induced GC→AT transition mutations. Such mutations are frequently seen in the KRAS oncogene of large colorectal adenomas, but whether adenoma or mutational risk in humans is influenced by...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMJ Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1856833/ https://ncbi.nlm.nih.gov/pubmed/16891355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2006.097899 |
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