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Heterogeneity of O(6)-alkylguanine DNA-alkyltransferase expression in human breast tumours
An important determinant of cellular resistance to chemotherapeutic O(6)-alkylating agents, which comprise methylating and chloroethylating agents, is the ability of cells to repair alkylation damage at the O(6)-position of guanine in DNA. This is achieved by a specific DNA repair enzyme O(6)-alkylg...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2375409/ https://ncbi.nlm.nih.gov/pubmed/12087469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600324 |
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