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Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour lines
Transformed cells have been documented to be methionine-dependent, suggesting that inhibition of methionine synthesis might be useful for cancer therapy. Methylenetetrahydrofolate reductase synthesises 5-methyltetrahydrofolate, the methyl donor utilised in methionine synthesis from homocysteine by v...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2376111/ https://ncbi.nlm.nih.gov/pubmed/12107847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600459 |
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