α–RgIA, a Novel Conotoxin that Blocks the α9α10 nAChR: Structure and Identification of Key Receptor Binding Residues

α-Conotoxins are small disulfide-constrained peptides from cone snails which act as antagonists at specific subtypes of nicotinic acetylcholine receptors (nAChRs). The 13-residue peptide α-RgIA is a member of the α-4,3 family of α-conotoxins and selectively blocks the α9α10 nAChR subtype, in contras...

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Bibliographische Detailangaben
Hauptverfasser: Ellison, Michael, Feng, Zhi-Ping, Park, Anthony J., Zhang, Xuecheng, Olivera, Baldomero M., McIntosh, J. Michael, Norton, Raymond S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376044/
https://ncbi.nlm.nih.gov/pubmed/18295795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.01.082
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