MDM2 gene SNP309 T/G and p53 gene SNP72 G/C do not influence diffuse large B-cell non-Hodgkin lymphoma onset or survival in central European Caucasians

BACKGROUND: SNP309 T/G (rs2279744) causes higher levels of MDM2, the most important negative regulator of the p53 tumor suppressor. SNP72 G/C (rs1042522) gives rise to a p53 protein with a greatly reduced capacity to induce apoptosis. Both polymorphisms have been implicated in cancer. The SNP309 G-a...

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Detalhes bibliográficos
Main Authors: Bittenbring, Joerg, Parisot, Frédérique, Wabo, Alain, Mueller, Monika, Kerschenmeyer, Lynn, Kreuz, Markus, Truemper, Lorenz, Landt, Olfert, Menzel, Alain, Pfreundschuh, Michael, Roemer, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375899/
https://ncbi.nlm.nih.gov/pubmed/18433491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-116
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