Homozygous G/G variant of SNP309 in the human MDM2 gene is associated with earlier tumor onset in Caucasian female renal cell carcinoma patients

Human mouse double minute 2 (Mdm2) plays an essential role in the regulation of the tumor suppressor p53. The G/G variant of SNP309 was shown to increase Mdm2 mRNA/protein expression and to be associated with an increased risk and earlier onset of different cancers in Asian populations. However, the...

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Vydáno v:Oncogenesis
Hlavní autoři: Stoehr, C G, Stoehr, R, Wenners, A, Hartmann, A, Bertz, S, Spath, V, Walter, B, Junker, K, Moch, H, Hinze, R, Denzinger, S, Bond, E E, Bond, G L, Bluemke, K, Weigelt, K, Lieb, V, Nolte, E, Fornara, P, Wullich, B, Taubert, H, Wach, S
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
Short Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154348/
https://ncbi.nlm.nih.gov/pubmed/26926790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2016.15
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