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Species differences in Cl(−) affinity and in electrogenicity of SLC26A6-mediated oxalate/Cl(−) exchange correlate with the distinct human and mouse susceptibilities to nephrolithiasis

The mouse is refractory to lithogenic agents active in rats and humans, and so has been traditionally considered a poor experimental model for nephrolithiasis. However, recent studies have identified slc26a6 as an oxalate nephrolithiasis gene in the mouse. Here we extend our earlier demonstration of...

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Hlavní autoři: Clark, Jeffrey S, Vandorpe, David H, Chernova, Marina N, Heneghan, John F, Stewart, Andrew K, Alper, Seth L
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375677/
https://ncbi.nlm.nih.gov/pubmed/18174209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.143222
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