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The kinetics of competitive antagonism of nicotinic acetylcholine receptors at physiological temperature

Detailed information about the ligand-binding site of nicotinic acetylcholine receptors has emerged from structural and mutagenesis experiments. However, these approaches provide only static images of ligand–receptor interactions. Kinetic measurements of changes in protein function are needed to dev...

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Bibliographic Details
Main Authors: Demazumder, Deeptankar, Dilger, James P
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375649/
https://ncbi.nlm.nih.gov/pubmed/18063662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.143289
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