Heterogeneity of O(6)-alkylguanine DNA-alkyltransferase expression in human breast tumours

An important determinant of cellular resistance to chemotherapeutic O(6)-alkylating agents, which comprise methylating and chloroethylating agents, is the ability of cells to repair alkylation damage at the O(6)-position of guanine in DNA. This is achieved by a specific DNA repair enzyme O(6)-alkylg...

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Autors principals: Clemons, M J, Bibby, M C, El Teraifi, H, Forster, G, Kelly, J, Banerjee, S, Cadman, B, Ryder, W D J, Howell, A, Margison, G P
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2002
Matèries:
Molecular and Cellular Pathology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375409/
https://ncbi.nlm.nih.gov/pubmed/12087469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600324
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