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Cell cycle phase perturbations and apoptosis in tumour cells induced by aplidine
Aplidine, dehydrodidemnin B, is a marine depsipeptide isolated from the Mediterranean tunicate Aplidium albicans currently in phase II clinical trial. In human Molt-4 leukaemia cells Aplidine was found to be cytotoxic at nanomolar concentrations and to induce both a G(1) arrest and a G(2) blockade....
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| Главные авторы: | , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2375382/ https://ncbi.nlm.nih.gov/pubmed/11986788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600265 |
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