Influence of epidermal growth factor receptor (EGFR), p53 and intrinsic MAP kinase pathway status of tumour cells on the antiproliferative effect of ZD1839 (‘Iressa’)

ZD1839 (‘Iressa’) is an orally active, selective epidermal growth factor receptor–tyrosine kinase inhibitor (EGFR–TKI), which blocks signal transduction pathways implicated in proliferation and survival of cancer cells, and other host-dependent processes promoting cancer growth. Permanent downstream...

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Detalhes bibliográficos
Main Authors: Magné, N, Fischel, J L, Dubreuil, A, Formento, P, Poupon, M-F, Laurent-Puig, P, Milano, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2002
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375374/
https://ncbi.nlm.nih.gov/pubmed/11986789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600299
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