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The bisphosphonate zoledronic acid impairs membrane localisation and induces cytochrome c release in breast cancer cells

Bisphosphonates are well established in the management of cancer-induced bone disease. Recent studies have indicated that these compounds have direct inhibitory effects on cultured human breast cancer cells. Nitrogen-containing bisphosphonates including zoledronic acid have been shown to induce apop...

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Autors principals: Senaratne, S G, Mansi, J L, Colston, K W
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2002
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375368/
https://ncbi.nlm.nih.gov/pubmed/11986784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600297
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