Analysis of CHK2 in vulval neoplasia

Structure and expression of the Rad53 homologue CHK2 were studied in vulval neoplasia. We identified the previously described silent polymorphism at codon 84 (A>G at nucleotide 252) in the germ-line of six out of 72, and somatic mutations in two out of 40 cases of vulval squamous cell carcinomas...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Reddy, A, Yuille, M, Sullivan, A, Repellin, C, Bell, A, Tidy, J A, Evans, D J, Farrell, P J, Gusterson, B, Gasco, M, Crook, T
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2002
Schlagworte:
Molecular and Cellular Pathology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375297/
https://ncbi.nlm.nih.gov/pubmed/11875739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600131
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