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IL-4 receptors on human medulloblastoma tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein

Cytotoxins directed to interleukin-4 receptors have shown to mediate relatively selective cytotoxicity against a variety of human cancer cells in vitro and in vivo. In an ongoing Phase I clinical trial, a recombinant protein comprised of circularly permuted IL-4 fused to a mutated form of Pseudomona...

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Библиографические подробности
Главные авторы: Joshi, B H, Leland, P, Silber, J, Kreitman, R J, Pastan, I, Berger, M, Puri, R K
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2002
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375174/
https://ncbi.nlm.nih.gov/pubmed/11870521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600034
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