InSite: a computational method for identifying protein-protein interaction binding sites on a proteome-wide scale

We propose InSite, a computational method that integrates high-throughput protein and sequence data to infer the specific binding regions of interacting protein pairs. We compared our predictions with binding sites in Protein Data Bank and found significantly more binding events occur at sites we pr...

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Main Authors: Wang, Haidong, Segal, Eran, Ben-Hur, Asa, Li, Qian-Ru, Vidal, Marc, Koller, Daphne
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2007
Teme:
Method
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375030/
https://ncbi.nlm.nih.gov/pubmed/17868464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2007-8-9-r192
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