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Protocol for Site-Specific Photo-Crosslinking Proteomics to Identify Protein-Protein Interactions in Mammalian Cells

Protein-protein interactions (PPIs) play essential roles in almost all aspects of cellular processes. However, PPIs remain challenging to study due to their substoichiometry, low affinity, dynamic nature, and context dependence. Here, we present a protocol for the capture and identification of PPIs...

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Detalhes bibliográficos
Publicado no:STAR Protoc
Main Authors: Chen, Chengjie, Peng, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756934/
https://ncbi.nlm.nih.gov/pubmed/33377005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xpro.2020.100109
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