Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery

BACKGROUND: Extant life depends greatly on the binding of small molecules (such as ligands) with macromolecules (such as proteins), and one ligand can bind multiple proteins. However, little is known about the global patterns of ligand-protein mapping. RESULTS: By examining 2,186 well-defined small-...

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Autors principals: Ji, Hong-Fang, Kong, De-Xin, Shen, Liang, Chen, Ling-Ling, Ma, Bin-Guang, Zhang, Hong-Yu
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2007
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375006/
https://ncbi.nlm.nih.gov/pubmed/17727706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2007-8-8-r176
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