Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery

BACKGROUND: Extant life depends greatly on the binding of small molecules (such as ligands) with macromolecules (such as proteins), and one ligand can bind multiple proteins. However, little is known about the global patterns of ligand-protein mapping. RESULTS: By examining 2,186 well-defined small-...

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Библиографические подробности
Главные авторы: Ji, Hong-Fang, Kong, De-Xin, Shen, Liang, Chen, Ling-Ling, Ma, Bin-Guang, Zhang, Hong-Yu
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2007
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375006/
https://ncbi.nlm.nih.gov/pubmed/17727706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2007-8-8-r176
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