Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns

BACKGROUND: Despite some degeneracy of sequence signals that govern splicing of eukaryotic pre-mRNAs, it is an accepted rule that U2-dependent introns exhibit the 3' terminal dinucleotide AG. Intrigued by anecdotal evidence for functional non-AG 3' splice sites, we carried out a human geno...

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Detalhes bibliográficos
Main Authors: Szafranski, Karol, Schindler, Stefanie, Taudien, Stefan, Hiller, Michael, Huse, Klaus, Jahn, Niels, Schreiber, Stefan, Backofen, Rolf, Platzer, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374985/
https://ncbi.nlm.nih.gov/pubmed/17672918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2007-8-8-r154
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