Selection against tandem splice sites affecting structured protein regions

BACKGROUND: Alternative selection of splice sites in tandem donors and acceptors is a major mode of alternative splicing. Here, we analyzed whether in-frame tandem sites leading to subtle mRNA insertions/deletions of 3, 6, or 9 nucleotides are under natural selection. RESULTS: We found multiple line...

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Main Authors: Hiller, Michael, Szafranski, Karol, Huse, Klaus, Backofen, Rolf, Platzer, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279118/
https://ncbi.nlm.nih.gov/pubmed/18366714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-8-89
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