Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer

Epidemiological studies have demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs), known to inhibit cyclooxygenase (COX), reduce the risk of colorectal cancer. COX is a key enzyme in prostaglandin biosynthesis, and two isoforms of COX, COX-1 and COX-2, have been identified. Recently COX-2...

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Detalhes bibliográficos
Main Authors: Tomozawa, S, Tsuno, N H, Sunami, E, Hatano, K, Kitayama, J, Osada, T, Saito, S, Tsuruo, T, Shibata, Y, Nagawa, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2000
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374554/
https://ncbi.nlm.nih.gov/pubmed/10917546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1270
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