Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells.

We have recently reported that S1P (sphingosine-1-phosphate) differentially regulates cellular Rac activity and cell migration in either a positive or a negative direction via distinct G-protein-coupled receptor subtypes, i.e. S1P1/Edg1 (endothelial differentiation gene) and S1P2/Edg5 respectively,...

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Detalhes bibliográficos
Main Authors: Yamaguchi, Hironori, Kitayama, Joji, Takuwa, Noriko, Arikawa, Kayo, Inoki, Isao, Takehara, Kazuhiko, Nagawa, Hirokazu, Takuwa, Yoh
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223636/
https://ncbi.nlm.nih.gov/pubmed/12803545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030381
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