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Inhibitory and Stimulatory Regulation of Rac and Cell Motility by the G(12/13)-Rho and G(i) Pathways Integrated Downstream of a Single G Protein-Coupled Sphingosine-1-Phosphate Receptor Isoform
The G protein-coupled receptors S1P(2)/Edg5 and S1P(3)/Edg3 both mediate sphingosine-1-phosphate (S1P) stimulation of Rho, yet S1P(2) but not S1P(3) mediates downregulation of Rac activation, membrane ruffling, and cell migration in response to chemoattractants. Specific inhibition of endogenous Gα(...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151702/ https://ncbi.nlm.nih.gov/pubmed/12588974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.5.1534-1545.2003 |
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