Inhibitory and Stimulatory Regulation of Rac and Cell Motility by the G(12/13)-Rho and G(i) Pathways Integrated Downstream of a Single G Protein-Coupled Sphingosine-1-Phosphate Receptor Isoform

The G protein-coupled receptors S1P(2)/Edg5 and S1P(3)/Edg3 both mediate sphingosine-1-phosphate (S1P) stimulation of Rho, yet S1P(2) but not S1P(3) mediates downregulation of Rac activation, membrane ruffling, and cell migration in response to chemoattractants. Specific inhibition of endogenous Gα(...

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Autores principales: Sugimoto, Naotoshi, Takuwa, Noriko, Okamoto, Hiroyuki, Sakurada, Sotaro, Takuwa, Yoh
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC151702/
https://ncbi.nlm.nih.gov/pubmed/12588974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.5.1534-1545.2003
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